Topics on transporter-mediated renal excretion and drug–drug interaction.

Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.

In humans and rats, a synergistic blood pressure reduction was observed when the fibrate gemcabene (CI-1027) was coadministered with the angiotensin-converting enzyme inhibitor quinapril. In a quinapril (3 mg/kg) pharmacokinetic rat study, there was a 40% decrease in urinary excretion and a 53% increase in plasma area under the curve from 0 to 24 h of the active metabolite quinaprilat when coad...

Situated interaction on spatial topics

The interaction on spatial topics is highly important no only in the context of mobile and situated systems but also in other fields such as natural language access to maps or user interfaces. Therefore, one goal of this thesis is to develop a generic model for situated interaction on spatial topics that can be used to build real world applications. In addition, we analyze typical problems that...

Effects of Renal Impairment on Transporter-Mediated Renal Reabsorption of Drugs and Renal DDI: A Simulation-Based Study

Simulation-Based Study K. E. Hill, R. A. Dave, M. E. Morris University at Buffalo Purpose Renal clearance (CLR) is an important pathway of elimination for drugs with poor metabolism and biliary clearance. The objectives of this study were to evaluate the effects of renal impairment (RI) on: (1) pharmacokinetics (PK) of a drug that undergoes renal transporter-mediated active reabsorption, (2) tr...

Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats.

The effects of Klebsiella pneumoniae endotoxin on the biliary excretion and renal handling of rhodamine-123 were investigated in rats at different times after intraperitoneal injection (1 mg/kg of body weight). The typical substrates for P glycoprotein, i.e., cyclosporine, colchicine, and erythromycin, inhibited the biliary clearance of rhodamine-123, whereas a substrate for organic cation tran...

Topics in Renal Disease